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Simple and Clean Procedure for Three-component Syntheses of Spiro{pyrido[2,1-b]benzothiazole-3,3'-indolines} and Spiro{thiazolo [3,2-a]pyridine-7,3'-indolines} in Aqueous Medium

Research Authors
Essam M. Hussein and Ahmed M. El-Khawaga
Research Abstract

A simple and efficient one-pot three component synthesis of spiro{pyrido[2,1-b]benzothiazole-3,3'-indoline} and/or spiro{thiazolo[3,2-a]pyridine-7,3'-indoline} derivatives were carried out by the reaction of 2-mercaptoaniline and/or mercaptoacetic acid, malononitrile, and a series of 2-oxoindoline-3-ylidines in aqueous medium. This method is of great value because of its environmentally benign character, high yield processing, and easy handling.

Research Department
Research Journal
J. Heterocyclic Chem.
Research Publisher
Wiley
Research Rank
1
Research Vol
In Press
Research Year
2011