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A Facile Synthesis of Some New 7,8-Dihydrospiro{imidazo[1,2-a]
pyridine-7,3'-indoline}-2'-one Derivatives

Research Authors
Maher F. El-Zohry, Thanaa
A. Mohamed, and Essam M. Hussein
Research Abstract

2-Methylimidazole (1) reacted with 3-dicyanomethylidine-1-ethyl-2-oxoindoline (2) in ethyl acetate to afford 5-amino-6-cyano-7,8-dihydro-1'-ethylspiro{imidazo[1,2-a]pyridine-7,3'-indolin}-2'-one (8), which used as a key intermediate for the synthesis of fused spiroheterocyclic derivatives of imidazo- pyridopyrimidine and/or imidazonaphthyridine nucleus incorporated indoline moiety. The chemical structures of all synthesized compounds were elucidated by the elemental and spectroscopic analyses.

Research Department
Research Journal
Heterocycles
Research Rank
1
Research Vol
Vol. 75 No. 11
Research Year
2008
Research Pages
pp. 2791-2802