A series of new pyrimidine, triazine, and isoindole heterocycles fused to the
selenolopyrazole ring system was synthesized by various condensation reactions
of the amino selenolopyrazole carboxamide 1, which was performed by
a new green methodology. The pyrimidinone compound 6 was used as a versatile
precursor for several aromatic nucleophilic substitution reactions to produce
the sulfanyl pyrimidines 10a‐c and the corresponding amines 11a‐c and
12a, b. Assignment of the chemical structures for the newly synthesized compounds
was confirmed by elemental and spectral analyses including Fourier
transform infrared (FTIR), 1H‐NMR, and 13C‐NMR and mass spectroscopy
for some of them. Furthermore, some of these compounds were screened
against various pathogenic bacterial and fungal strains. Their results demonstrated
that some of them revealed remarkable antimicrobial activities.