Hepatoprotective Activity of Ficus sycomorus L. Against N-Nitrosodiethylamine and CCl4-Induced Hepatocarcinogenesis in Experimental Rats

Faculty of Pharmacy

Assiut University

Hepatoprotective Activity of Ficus sycomorus L. Against N-Nitrosodiethylamine and CCl4-Induced Hepatocarcinogenesis in Experimental Rats

Research Authors
Samia M. El-Sayyad, Makboul A. Makboul, Rofida M. Ali, Jasmine O. El-Amir, Salwa F. Farag
Research Department
Department of Pharmacognosy
Research Journal
Research & Reviews: Journal of Pharmacognosy and Phytochemistry (JPRPC)
Research Publisher
NULL
Research Rank
1
Research Vol
Vol. 3, No. 3
Research Website
NULL
Research Year
2015
Research Member
Samia Mohamed El-Sayyad El-Semary
Research Abstract

The hepatoprotective activity of the different extracts of Ficus sycomorus L. (FS) against N nitrosodiethylamine (NDEA) and CCl4-induced hepatocarcinogenesis (HCC) in rats has been investigated for the first time. Histological observations of liver tissues demonstrated that, both wood (FSWE) and leaf extracts (FSLE) possess significant hepatoprotective activity and stem bark extract (FSBE) shows moderate activity while fruit extract (FSFE) is not significantly effective.