A polymerized film of eriochrome black T
(EBT) was prepared on the surface of pencil graphite
electrode in alkaline solution by cyclic voltammetry. The
redox response of the poly (EBT) film at the electrode
appeared in a couple of redox peak in 0.1 M sodium
hydroxide. The poly (EBT) film-coated electrode exhibited
excellent electrocatalytic activity towards the oxidation
of rabeprazole sodium (RAB sodium) and domperidone
(DOM) in Britton-Robinson buffer (pH 4.0). The
polymer film modified electrode conspicuously enhanced
the redox currents of the cited mixture and could
sensitively and separately determine them. Both cyclic
voltammetry (CV) and square wave adsorptive stripping
voltammetric (SWAdSV) methods were utilized to determine
this mixture. The linearity of CV ranged from 4.1-
120 mM and 5.2-90 mM for RAB sodium and DOM,
respectively while SWAdSV was 7.5-803107M and 5–
703107M for RAB sodium and DOM, respectively. With
good selectivity and sensitivity, the present method
provides a simple method for selective detection of RAB
sodium and DOM binarybinary mixture in synthetic mixtures
and biological fluids.