Square wave adsorptive stripping voltammetric
(SQWASV) method has been utilized to confirm and elucidate
the possible complexation reaction between pantoprazole
sodium and cobalt as a transition metal in Britton-
Robinson buffer (pH=7.0). The current signal due to
the oxidation process was a function of the amount of
pantoprazole sodium, pH of the medium, cobalt concentration
and accumulation time at the electrode surface.
The oxidation peak current has varied linearly with the
concentration over the range of 0.1–9.0 nM. The limit of
detection was found to be 0.04 nM. The validity of the
method was successfully applied for the determination of
pantoprazole sodium in pharmaceutical formulations with
a pharmacokinetic study in rabbit plasma. The simplicity,
rapidity, sensitivity and selectivity of this method make it
a very attractive alternative to the other existing methods
in the quality control laboratories.