Different Chromatographic and Electrophoretic Methods for Analysis of Proton Pump Inhibitors (PPIs): A Review

Faculty of Pharmacy

Assiut University

Different Chromatographic and Electrophoretic
Methods for Analysis of Proton Pump Inhibitors
(PPIs): A Review

Research Authors
Michael E. El-Kommos, Pakinaz Y. Khashaba, Hassan Refat H. Ali & Mohamed M. El-Wekil
Research Department
Department of Pharmaceutical Analytical Chemistry
Research Journal
Journal of Liquid Chromatography & Related
Technologies
Research Publisher
Taylor& Francis
Research Rank
1
Research Vol
Vol. 38
Research Website
NULL
Research Year
2015
Research Member
Mohamed Mahmoud Abdel-Gaber El-Wekil
Research Abstract

A systematic comprehensive review of literature for the analysis of the most recent antiulcer drugs and proton pump inhibitors (PPIs) by different chromatographic and electrophoretic methods are presented. The review includes literature from 1985 until 2015 on eight proton pump inhibitors; namely: omeprazole (OMZ), lansoprazole (LAN), pantoprazole (PAN), rabeprazole (RAB), esomeprazole (EMZ),
dexlansoprazole (DLAN), dexrabeprazole (DRAB), and tenatoprazole (TNB). The investigated literature survey covers most chromatographic and electrophoretic methods used for the assay of these drugs in pure forms, in combined mixtures, in pharmaceutical dosage forms, and in biological fluids.