Abstract Background: Educational program today is very important for the nurses to increase knowledge and practice for immediate care of cystectomy.Aim to: evaluate the effect of educational program on nurses` knowledge and practice for immediate care of post cystectomy patients at intensive care unit. Research design : A quasi experimental design was conducted to achieve the aim of the study. Subjects: All available nurses' were 40 nurses caring for patients with cystectomy. Two tools were used for data collection, tool one, knowledge assessment structured interviewing questionnaire and tool two, an observational checklist. Results: Nurses` knowledge scores improved after implementation of the educational program from (15% to 97.5%), also the observed nurses` practice scores were improved from (20%) before the educational program to (100%) after the educational program .Conclusion: Nurses` knowledge and practice regarding the immediate care of patients with cystectomy becomes satisfactory level after the educational program. Recommendations: The study recommends focused on establishing plans by periodical educational programs for nurses to help them in improving their knowledge and practice.