Abstract Background: Severe traumatic brain injury (STBI) is a serious medical condition that is associated with considerable disease burden and disability throughout the world. Clinical pathways provide the means to connect the best available evidence with clinical practice to improve patient outcomes. Objective: To measure the effectiveness of implementing a clinical pathway to usual care on the complications related to severe traumatic brain injury. Design: Quasi-experimental study.Methods: A convenience sampling of 60 adult patients with TBI were recruited, with 30 patients assigned to the control group and 30 to the pathway group. The study was conducted at the trauma ICU of Assiut Hospital, Egypt. The control group received 15 days of ICU routine care and intervention group received 15 day of care includes in the clinical pathway. Results: The study found fewer complications related to TBI in the clinical pathway group, with statistically significant differences found between groups. Patients in the clinical pathway group demonstrated significantly fewer cases of prolonged mechanical ventilation and reintubation. Conclusion: The current study suggests that the implementation of a clinical pathway for severe TBI may be effective in decreasing the frequency of complications related to severe TBI.