A field experiment was carried out at the Department of Agronomy Experimental Farm, Faculty of Agriculture, Assiut University, during the growing seasons 2017/18 and 2018/19 to study the impact of foliar spray by some Nano Micro-nutrients on grain yield and quality of three cultivars of bread wheat. Randomized complete block design (RCBD) was used in this experiment in three replications using strip plot arrangement. The bread wheat varieties i.e., Sids-1, Sids-12, and Gemmeaza-11 were arranged vertically, while foliar sprays with tap water (solvent as a control) and Iron, Manganese, Zinc, Iron + Manganese, Iron + Zinc, Manganese+ Zinc and Iron + Manganese + Zinc in Nano form at 200 ppm concentration were distributed horizontally. In both seasons, the foliar spray treatment with certain micronutrient nano-particles had a significant impact on grain yield, flour percentage, coarse bran percentage, wet gluten percentage, and dry gluten percentage. As a result, wheat plants sprayed with Fe + Mn + Zn had the greatest average values of the previous traits. Furthermore, the cultivars studied had a substantial impact on the majority of the traits studied. In addition, in both seasons, the Sids-1 cultivar produced the greatest mean values of the most investigated traits. In both the 1st and 2nd seasons, the interaction between some micro-nutrients, nano-particles, and cultivars had a significant (P ≤ 0.05) and highly significant (P ≤ 0.01) impact on fermentation time. In this approach, the Sids-12 cultivar, which was sprayed with Mn+Zn in the 1st season, and the same cultivar when sprayed with Mn or Fe+Zn in the 2nd season, yielded the most elevated mean values of fermentation time (37.00 and 36.50 minutes within the two seasons).