A field experiment wasconducted during the 2019 and 2020 summer seasons to investigate the effect of different weed control treatments namely; Butralin as pre-emergence herbicide (2.5 L/fed.), butralin (2.5 L/ fed.) + hand hoeing once at 30 days after planting (DAP), hand hoeing thrice at 15, 30 and 45 DAP and un-weeded treatment under different planting methods, i.e., rows and raised beds planting, on weeds density, yield and its attributes of Giza 90 cotton cultivar. Results indicated that, the density of the weeds was decreasedsignificantly with all studied weed control treatments compared with un-weeded treatment (control) in the two growing seasons. In addition, the plant height, number of sympodial branches, opening bolls per plant, seed weight and seed cotton yield were also increased with allstudied weed control treatmentsover weedy check. As well as, hand hoeing thrice at 15,30 and 45 DAP treatment gave a significantly higher seed cotton yield as compared to the other studied weed control treatments in both seasons. Furthermore, the obtained result showed that among the tested planting methods, beds width 120 cm planting gave the best results in terms of controlling weeds, reducing dry weight of weeds, increasing sympodial branches plant^-1, total number of bolls plant^-1, number of mature bolls plant^-1, seed cotton weight